ISSN ONLINE 2583- 2247

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Salivary Gland Tumors: A Narrative Review with Emphasis on Clinicopathological Features

Himani Tiwari* and Piyush Asnani

1Department of Oral and Maxillofacial Pathology, Faculty of Dental Sciences, Dharmsinh Desai University, Nadiad, Gujarat India .

Corresponding author Email: himanicsc@gmail.com


Salivary gland tumors represent a diagnostically challenging group of lesions due to their marked histological diversity, wide biological behaviour, and overlapping clinical features. These neoplasms arise from both major and minor salivary glands and encompass a broad spectrum ranging from indolent benign entities to aggressive malignant tumors with a propensity for local invasion and distant spread. Accurate diagnosis is essential, as treatment strategies and prognostic outcomes vary significantly depending on tumor type, grade, and anatomical site.

This narrative review provides a structured overview of salivary gland tumors with emphasis on their clinicopathological characteristics and diagnostic considerations. The classification of salivary gland neoplasms is discussed in accordance with contemporary World Health Organization (WHO) guidelines, highlighting key benign and malignant epithelial tumors encountered in routine practice. Salient clinical presentations, histomorphological features, and patterns of biological behaviour relevant to diagnosis and management are outlined.

The role of diagnostic modalities including clinical examination, imaging techniques, fine-needle aspiration cytology, and histopathological evaluation is reviewed, with particular emphasis on the strengths and limitations of each approach. Management principles and current perspectives on surgical and adjuvant treatment strategies are briefly addressed. Our knowledge of salivary gland pathology has advanced significantly in recent years, molecular diagnostic approaches are being used in an effort to find viable therapy drugs for salivary duct carcinomas. There have been descriptions of concepts like "high-grade transformation," which not only affect the macroscopic and microscopic assessment of a specimen but also have important treatment implications due to the high prevalence of metastases and morbidity. Fluorescent in situ hybridization can identify some chromosomal translocations, which can improve diagnostic precision and have prognostic consequences.

This review aims to serve as a concise yet comprehensive reference for dental practitioners, oral pathologists, and postgraduate students involved in the diagnosis and management of salivary gland tumors.


Classification; Clinical behaviour; Histopathological features; Management strategies; Neoplasia; Salivary gland tumors

Copy the following to cite this article:

Tiwari H, Asnani P. Salivary Gland Tumors: A Narrative Review with Emphasis on Clinicopathological Features. Enviro Dental Journal 2026;8(1).

Copy the following to cite this URL:

Tiwari H, Asnani P. Salivary Gland Tumors: A Narrative Review with Emphasis on Clinicopathological Features. Enviro Dental Journal 2026;8(1). Avialable here: https://bit.ly/3O2sATf


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